個(gè)人簡(jiǎn)介：
趙燕，生命科學(xué)學(xué)院神經(jīng)生物學(xué)系副教授，博士生導(dǎo)師，基金委優(yōu)秀青年科學(xué)基金獲得者，于2020年11月全職回國(guó)加入南方科技大學(xué)生命科學(xué)學(xué)院。趙燕本科和博士均畢業(yè)于北京大學(xué)醫(yī)學(xué)部，并先后在中國(guó)科學(xué)院生物物理所和美國(guó)馬薩諸塞大學(xué)醫(yī)學(xué)院進(jìn)行博士后工作，進(jìn)行細(xì)胞自噬的分子機(jī)制和生理功能研究，以第一作者和/或通訊作者身份在Molecular Cell、Current Biology、JCB、Autophagy、Cell reports等國(guó)際頂尖學(xué)術(shù)期刊發(fā)表論文多篇。
研究領(lǐng)域：
自噬是細(xì)胞內(nèi)重要的降解機(jī)制，對(duì)于維持細(xì)胞穩(wěn)態(tài)至關(guān)重要。在體內(nèi)，自噬保障了機(jī)體各器官的正常生理功能，自噬異常導(dǎo)致多種人類疾病的發(fā)生發(fā)展。課題組未來(lái)的研究方向主要集中在研究多細(xì)胞特有自噬蛋白在自噬過(guò)程中的分子機(jī)制和體內(nèi)功能，具體包括以下方向：
1. 研究自噬小體形成過(guò)程中，內(nèi)質(zhì)網(wǎng)與自噬前體結(jié)構(gòu)的相互作用的調(diào)控和功能
2. 研究神經(jīng)細(xì)胞自噬的特有分子機(jī)制，尋找神經(jīng)退行性疾病的潛在治療靶點(diǎn)
3. 研究?jī)?nèi)質(zhì)網(wǎng)與細(xì)胞內(nèi)其他細(xì)胞器相互作用的分子組成、調(diào)節(jié)機(jī)制和生理功能
4. 研究冠狀病毒轉(zhuǎn)錄復(fù)制過(guò)程中雙層膜囊泡（DMV）的形成機(jī)制
代表文章：
1.Li, M., Hou, Y., Zhou, Y., Yang, Z., Zhao, H., Jian, T., Yu, Q., Zeng, F., Liu, X., Zhang, Z., and Zhao, Y.G. (2024). LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation. J Cell Biol 223 e202309140.
2.Ji, M., Li, M., Sun, L., Zhao, H., Li, Y., Zhou, L., Yang, Z., Zhao, X., Qu, W., Xue, H., Zheng, Z., Li, Y., Deng, H., and Zhao, Y.G. (2022) VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection. J Cell Biol 221, e202112081.
3. Ji, C., Zhao, H., Zhang, H., and Zhao, Y.G. (2021) β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells. Curr Biol 31, 1666-1677.
4. Ji, C., Zhao, H., Li, D., Sun, H., Hao, J., Chen, R., Wang, X., Zhang, H., and Zhao, Y.G. (2020) Role of Wdr45b in maintaining neural autophagy and cognitive function. Autophagy 16, 615-625.
5. Li, D., Zhao, Y.G.*, Li, D., Zhao, H., Huang, J., Miao, G., Feng, D., Liu, P., Li, D., and Zhang, H. (2019) The ER-localized protein DFCP1 modulates ER-lipid droplet contact formation. Cell Rep 27, 343-358. (*Zhao, Y.G. as co-first author)
6. Zhao, Y.G., Liu, N., Miao, G., Chen, Y., Zhao, H., and Zhang, H. (2018) The ER contact proteins VAPA/B interact with multiple autophagy proteins to modulate autophagosome biogenesis. Curr Biol 28, 1234-1245.
7. Zhao, Y.G., Chen, Y., Miao, G., Zhao, H., Qu, W., Li, D., Wang, Z., Liu, N., Li, L., Chen, S., Liu, P., Feng, D., and Zhang, H. (2017) The ER-localized transmembrane protein EPG-3/VMP1 regulates SERCA activity to control ER-isolation membrane contacts for autophagosome formation. Mol Cell 67, 974-989.
8. Zhao, Y.G., Sun, L., Miao, G.Y., Ji, C.C., Zhao, H.Y., Sun, H.Y., Miao, L., Yoshii, S.R., Mizushima, N., Wang X.Q., and Zhang, H. (2015) The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis. Autophagy 11, 881-890.
9. Zhao, Y.G.*, Zhao, H.Y., Sun, H.Y., and Zhang, H. (2013) Role of Epg5 in selective neurodegeneration and Vici syndrome. Autophagy 9, 1185-1189. (*Zhao, Y.G. as first author and co-corresponding author)
10. Zhao, H.Y., Zhao, Y.G.*, Wang, X.W., Xu, L.J., Miao, L., Feng, D., Chen, Q., Kovács, A.L. Fan, D.S., and Zhang, H. (2013) Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration. J Cell Biol 200, 731-741. (*Zhao, Y.G. as co-first author and co-corresponding author)
11. Zhao, Y.G., Zhao, H.Y., Miao, L., Wang, L., Sun, F., and Zhang, H. (2012) The p53-induced gene Ei24 is an essential component of the basal autophagy pathway. J Biol Chem 287, 42053-42063.
